IMHO it all depends on what you want to do.
1. If you want to take a chance at pulling a Jace, Architect of Thought
and don't want to shell out $40 for a card, your only other option is
to open lots of packs, and a booster box is ideal for that.
2. If you
like cool surprises or want a bunch of what a set offers, even if the
cards aren't selling for much, then a booster box I think is just
perfect. I wanted to have a lot of artifacts and not just at common and
uncommon only and opened a booster box of Scars of Mirrodin. I had a
blast. I even pulled a Wurmcoil Engine !!! and a foil Molten-tail Masticore
3.
If you really like one of the large sets, a common/uncommon playset is
great. My only gripe is that the complete common playset is a ton of
cards, and has playsets of all those commons that work for 15 minutes in
limited and then are relegated to storage boxes to collect dust. I wish
more uncommon-only playsets were sold. Still, once a set has been out
for a while, these playsets are a great bargain. Even with a booster box
you don't even get close to having a common/uncommon playset. With the
box of Scars of Mirrodin I am still missing one common!!!
4. I am
liking the intro packs more and more, and especially the battle packs.
These out-of-the-box are a little weak, but all the fun is in opening
the packs that come with this product and boosting the content in the
pre-made pack.
Even though ebay sellers and the online bots
perform a needed service, when in doubt, I am all for sealed product
untouched by non-Wizards.